On the first years of the nanotechnology “fever”, nanoparticles were synthesized with very little control of size, shape, composition and crystalline structure. Now, it is clear that if real applications are to be developed, much higher synthesis control is required. In order to address this challenge and be able to make an impact in our daily life; a new synthesis protocol has to be developed, to design reproducible and innovative nanomaterials. To create new nano/quantum materials with well-defined crystalline structure and physico-chemical properties that cannot be achieved by using traditional wet-chemistry techniques, Pulsed Laser Ablation in Liquids is going to be adopted as our synthesis protocol. Furthermore, in order to speed up the development of those nanomaterials, quantum/nano-thermodynamics will be used to look experimentally for structures predicted on a theoretical basis. This strategy has already been used with success in my previous publications1. Consequently, this unique approach enhances the fundamental understanding of nanomaterials and paves the way for unparalleled innovations2,3!