Experiments in high energy density science (HEDS) have practical applications for society ranging from studies that support the development of fusion energy platforms to providing scientific data that supports sustainment of the US nuclear deterrent.  HEDS more broadly encompasses the study of matter at extreme temperatures and densities, ranging from those relevant to planetary science and stellar evolution to those created in inertial confinement fusion experiments.  In this presentation, I will give an overview of ongoing experiments in materials, plasma, and nuclear science at the National Ignition Facility, including a few examples of how ignition opens new possibilities for expanding our basic science experiments.  This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.